Epigenetic regulation of epithelial–mesenchymal transition

Transcriptional and Epigenetic Regulation of Epithelial- Mesenchymal Transition

Tan, E.-J. 2013. Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 928. 51 pp. Uppsala. ISBN 978-91-554-8734-8. The transforming growth factor beta (TGFβ) is a cytokine that regulates a plethora of cellular processes such as cell proliferation, diff...

Epigenetic Regulation of Adipokines

Adipose tissue expansion in obesity leads to changes in the expression of adipokines, adipocyte-specific hormones that can regulate whole body energy metabolism. Epigenetic regulation of gene expression is a mechanism by which cells can alter gene expression through the modifications of DNA and histones. Epigenetic mechanisms, such as DNA methylation and histone modifications, are intimately ti...

Epigenetic regulation in plants.

The study of epigenetics in plants has a long and rich history, from initial descriptions of non-Mendelian gene behaviors to seminal discoveries of chromatin-modifying proteins and RNAs that mediate gene silencing in most eukaryotes, including humans. Genetic screens in the model plant Arabidopsis have been particularly rewarding, identifying more than 130 epigenetic regulators thus far. The di...

Sirtuins in Epigenetic Regulation

Epigenetic regulation in chondrogenesis.

Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the acce...